[WIP] Regenerating the Tooth

From dentin to enamel

Enamel:

Lorem

Fluorapatite

Hydroxyapatite/Nano-hydroxyapatite

Casein phosphopeptide–amorphous calcium phosphate (CPP-ACP)
- Stabilizes calcium and phosphate ions, keeping them bioavailable for remineralisation.
Derived from milk.
Lactose also helps calcium absorption.

https://www.reddit.com/r/ScienceNcoolThings/comments/1j7lciw/guidebest_toothpastes_according_to_my_exhaustive/

Bioactive glass (calcium sodium phosphosilicate)/NovaMin

Keratin/collagen

Arginine + calcium carbonate

Peptides:
P11-4

Amelogenin Peptide-Chitosan Hydrogel for Biomimetic Enamel Regrowth

https://www.dentinova.co.uk/2025/06/30/biomimetic-enamel-regeneration-liquid/

https://en.wikipedia.org/wiki/Oligopeptide_P11-4

Calcium silicate

Amelogenesis, Amelogenin, Ameloblastin, Enamelin, Tuftelin, amelotin

Xylitol

Weston A Price nutrition

• Vitamin D

  • Regulates calcium and phosphate absorption in the gut.

  • Stimulates production of antimicrobial peptides in saliva.

  • Deficiency → hypomineralisation of enamel, increased caries risk.

  • Important for both systemic tooth formation and ongoing mineral balance.

• Vitamin K2 (menaquinone)

  • Works synergistically with vitamin D and calcium.

  • Activates proteins (like osteocalcin, matrix Gla protein) that direct calcium to bone and teeth, preventing soft tissue calcification.

  • Evidence is growing but not fully mainstream in dentistry yet.

• Vitamin A

  • Needed for epithelial health, enamel organ development, and saliva function.

  • Severe deficiency causes enamel hypoplasia.

• Vitamin C

  • Critical for collagen synthesis in dentin and periodontal tissues.

  • Indirect effect on enamel (since enamel is acellular once formed), but healthy gums/saliva help maintain remineralisation balance.

• Calcium & Phosphate

  • Direct raw materials for remineralisation.

  • Found in dairy, leafy greens, almonds, fish with bones.

  • Saliva normally maintains these ions around enamel, but diet boosts systemic supply.

• Magnesium

  • Stabilises hydroxyapatite structure.

  • Deficiency may impair mineralisation.

• Trace minerals (Zinc, Iron, Strontium, Silica)

  • Small supportive roles in enamel strength or bacterial control.

  • Strontium can substitute for calcium in hydroxyapatite, making it more acid-resistant (some remineralising toothpastes use strontium salts).

Antibacterials

Dentin:

Lorem